Genetic Interactions: Online supplement to:

Owen Ozier, Nada Amin, Trey Ideker. Global architecture of genetic interactions on the protein network. Nature Biotechnology, May 2003; 21(5):490-1

As with all research, we performed far more experiments for this project than are reported in the publication itself; here, we describe the details of our data and methods, as well as a number of variations on the methods that followed from our line of reasoning.

Thanks to Chen-Hsiang Yeang, Linda and Lance Ozier, Gary Bader, Benno Schwikowski, Nick Matsakis, Ziv Bar-Joseph, and members of David Gifford and Tommi Jaakola's groups at MIT for insightful discussions about this work.