As with all research, we performed far more experiments for this project than are reported in the publication itself; here, we describe the details of our data and methods, as well as a number of variations on the methods that followed from our line of reasoning.
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Getting started
- Where did the physical network for the paper come from?
- How can I download the physical network?
- Where did the genetic network for the paper come from?
- How did the total number of genetic interactions end up 1312?
- How can I download the genetic network?
- Do protein connections correlate with single-deletion lethality?
- How would using different connectivity metrics (arithmetic mean, geometric, etc.) affect the observations and conclusions of the paper?
- How does the choice of model for expected genetic interaction distribution affect the observations and conclusions of the paper?
- How does the choice of physical and genetic network data (DIP, BIND, Lee et al, etc.; lethal vs supressor, etc.) affect the observations and conclusions of the paper?
- How likely is it that two hubs have the same functional classification (MIPS category)? What implications does this have for the conclusions of the paper?
Basic questions
Advanced variations